TETi76 is an orally active TET family inhibitor with IC50 values of 1.5, 9.4 and 8.8 µM for TET1, TET2 and TET3, respectively. TETi76 competitively binds to the active site of TET enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of TET2 mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research[1].
Molecular Weight:
216.23
Purity:
97.49
CAS Number:
[1451750-73-4]
Formula:
C10H16O5
Target:
TET Protein
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
