(+)-JJ-450, CAS [[1998094-24-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-403733B
Supplier Catalog Number:
HY-403733B
Alternative Catalog Number:
MCE-HY-403733B-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
(+)-JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR) that inhibits AR nuclear localization and transcriptional activity in the absence of androgen. (+)-JJ-450 is less active than (-)-JJ-450 (HY-403733A) in inhibiting prostate-specific antigen (PSA) expression in LN95 cells, possibly because (+)-JJ-450 targets the ligand binding domain (LBD) of AR. (+)-JJ-450 inhibits the transcriptional activity of AR and its splice variants (e.g., ARv7) by promoting the degradation of unliganded AR in the nucleus and reducing the binding of AR to androgen response elements (AREs). (+)-JJ-450 can be used in castration-resistant prostate cancer (CRPC) studies that are resistant to enzalutamide (MDV3100) (HY-70003)[1].
Molecular Weight:
372.86
CAS Number:
[1998094-24-8]
Formula:
C21H22ClFN2O
Target:
Androgen Receptor,Prostaglandin Receptor
Application Notes:
MCE Product type: Reference compound
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