MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy[1][2].
Molecular Weight:
459.50
Purity:
99.85
CAS Number:
[845256-65-7]
Formula:
C25H28F3N3O2
Target:
Apoptosis,Kinesin,Lipoxygenase
Application Notes:
MCE Product type: Reference compound
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