Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRbeta, and FLT3, respectively. Linifanib shows prominent antitumor activity. Linifanib has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib is a specific miR-10b inhibitor that blocks miR-10b biogenesis[1][2].
Molecular Weight:
375.40
Purity:
99.72
CAS Number:
[796967-16-3]
Formula:
C21H18FN5O
Target:
Apoptosis,Autophagy,c-Fms,c-Kit,FLT3,PDGFR,VEGFR
Application Notes:
Reference compound
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