Daporinad (FK866) is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a Ki value of 0.3 nM. Daporinad depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad causes the depletion of the endoplasmic reticulum Ca pool, ultimately weakening the mitogen-induced Ca signal and the activation and function of T cells. Daporinad induces cell cycle arrest and apoptosis, and inhibits cell proliferation. Daporinad can be used for the study of myeloma, liver cancer, and immunosuppression[1][2][3][4].
Molecular Weight:
391.51
Purity:
99.91
CAS Number:
[658084-64-1]
Formula:
C24H29N3O2
Target:
Apoptosis,Autophagy,ERK,mTOR,NAMPT,p38 MAPK
Application Notes:
MCE Product type: Reference compound
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