Crizotinib (hydrochloride), CAS [[1415560-69-8]]

Product Overview

• Article Name: Crizotinib (hydrochloride), CAS [[1415560-69-8]]
• Biozol Catalog Number: MCE-HY-50878A
• Supplier Catalog Number: HY-50878A
• Alternative Catalog Number: MCE-HY-50878A-100MG,MCE-HY-50878A-10MG,MCE-HY-50878A-200MG,MCE-HY-50878A-10MMX1ML,MCE-HY-50878A-50MG,MCE-HY-50878A-5MG,MCE-HY-50878A-500MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: PF-02341066 (hydrochloride)

Product Description

Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition[1][2][3].

Product Properties

• Molecular Weight: 486.80
• Purity: 99.86
• CAS Number: [1415560-69-8]
• Formula: C21H23Cl3FN5O
• Target: Anaplastic lymphoma kinase (ALK),Autophagy,c-Met/HGFR,ROS Kinase

Application Notes

• Application Notes: MCE Product type: Reference compound