Gefitinib-d3 (ZD1839-d3) is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
Molecular Weight:
449.92
CAS Number:
[1173976-40-3]
Formula:
C22H21D3ClFN4O3
Target:
Autophagy,EGFR,Isotope-Labeled Compounds
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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