Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment[1][2][3].
Molecular Weight:
764.86
Purity:
99.08
Formula:
C39H40D3N3O11S
Target:
Apoptosis,Isotope-Labeled Compounds,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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