A-582941 is a selective, orally active, blood-brain barrier-permeable alpha7 nAChR agonist, with Ki values of 10.8 nM and 17 nM in rat brain and human frontal cortex, respectively. A-582941 exhibits agonistic activity at 5-HT3 receptors, with a Ki of 150 nM. A-582941 triggers phosphorylation of ERK1/2 and CREB, inhibits GSK-3beta via Ser-9 phosphorylation, increases acetylcholine release, induces the expression of Arc and c-Fos, activates brain regions associated with working memory and attention, and reduces cell death caused by nerve growth factor (NGF) deprivation. A-582941 is applicable for the research of Alzheimers disease and schizophrenia[1][2][3].
Molecular Weight:
280.38
CAS Number:
[848591-89-9]
Formula:
C17H20N4
Target:
5-HT Receptor,Epigenetic Reader Domain,ERK,nAChR
Application Notes:
MCE Product type: Reference compound
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