Alosetron (GR 68755) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2].
Molecular Weight:
294.35
Purity:
96.26
CAS Number:
[122852-42-0]
Formula:
C17H18N4O
Target:
5-HT Receptor
Application Notes:
MCE Product type: Reference compound
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