Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis[1].
Molecular Weight:
445.61
Purity:
99.71
CAS Number:
[1026785-55-6]
Formula:
C25H35NO4S
Target:
DNA/RNA Synthesis,HCV
Application Notes:
MCE Product type: Reference compound
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