Tianeptine is an atypical antidepressant. Tianeptine is a moderate-intensity agonist of the µ-opioid receptor (MOR), and to a lesser extent, is an agonist of the delta-opioid receptor (DOR). Tianeptine is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. tianeptine increases sensitivity of the alpha1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-kappaB pathway. Tianeptine can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects[1][2][3][4][5].
Molecular Weight:
436.95
Purity:
99.84
CAS Number:
[72797-41-2]
Formula:
C21H25ClN2O4S
Target:
Akt,iGluR,MMP,NF-kappaB,Opioid Receptor,PI3K
Application Notes:
MCE Product type: Reference compound
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