Naloxegol (NKTR-118, AZ-13337019) is an orally active peripherally acting µ-opioid receptor antagonist with a target Ki of 7.42 nM. Naloxegol inhibits the binding of opioids to µ-opioid receptors in the gastrointestinal tract, and alleviates opioid-induced gastrointestinal hypomotility, delayed transit, hypertonicity, and increased fluid reabsorption. Naloxegol is applicable to research related to opioid-induced constipation[1][2].
Molecular Weight:
651.78
CAS Number:
[854601-70-0]
Formula:
C34H53NO11
Target:
Opioid Receptor
Application Notes:
MCE Product type: Reference compound
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