Halofantrine hydrochloride (SKF-102886 hydrochloride, WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent. Halofantrine hydrochloride inhibits the Cap1-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria[1][2].
Molecular Weight:
536.88
Purity:
99.90
CAS Number:
[36167-63-2]
Formula:
C26H31Cl3F3NO
Target:
Fungal,Parasite,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound1
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