Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 µM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1[1][2][3].
Molecular Weight:
416.35
Purity:
99.43
CAS Number:
[147059-72-1]
Formula:
C20H15F3N4O3
Target:
Antibiotic,Bacterial,Topoisomerase
Application Notes:
MCE Product type: Reference compound1
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