Pamidronic acid (sodium), CAS [[89131-02-2]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-B0012B
Supplier Catalog Number:
HY-B0012B
Alternative Catalog Number:
MCE-HY-B0012B-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Pamidronic acid sodium, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid sodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid sodium can inhibit the signaling of Wnt and beta-catenin, and is applicable for research on osteoporosis and osteosarcoma[1][2][3][4].
