Tropisetron is an orally active 5-HT3R antagonist (Ki = 5.3 nM) as well as being a potent and selective alpha7 nicotinic partial agonist (EC50 = 1.3 µM). Tropisetron prevents phosphorylation and activation of the p38 MAPK. Tropisetron inhibits both IL-2 gene transcription and IL-2 synthesis in stimulated T cells. Tropisetron inhibits the binding to DNA and the transcriptional activity of NFAT and AP-1. Tropisetron is anti-inflammatory and antiemetic. Tropisetron has antitumor and neuroprotective effects. Tropisetron can be studied in research for diseases including hemorrhagic cystitis, chronic joint inflammation, lung cancer and chronic cerebral hypoperfusion[1][2][3][4][5][6].
Molecular Weight:
284.36
Purity:
99.93
CAS Number:
[89565-68-4]
Formula:
C17H20N2O2
Target:
5-HT Receptor,AP-1,JAK,nAChR,NF-kappaB,Nuclear Factor of activated T Cells (NFAT),p38 MAPK
Application Notes:
MCE Product type: Reference compound
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