Mycophenolate mofetil (RS 61443, TM-MMF) is an orally active antimetabolic immunosuppressant with antiproliferative and anti-inflammatory properties. Mycophenolate Mofetil significantly inhibits the production of B, T lymphocytes and the proliferation of smooth muscle cells by selectively blocking the de novo purine synthesis pathway. Mycophenolate Mofetil effectively reduces adventitial inflammation, medial necrosis and intimal thickening in rat aortic allografts, and decreases the number of lymphocytes expressing the IL-2 receptor, thereby delaying xenograft rejection. Mycophenolate Mofetil shows certain toxicity in a hamster-to-rat limb xenotransplantation model when used in combination with FK506 (HY-13756). Mycophenolate Mofetil is widely used in studies related to allograft arteriosclerosis (chronic rejection)[1][2].
Molecular Weight:
433.49
Purity:
99.83
CAS Number:
[128794-94-5]
Formula:
C23H31NO7
Target:
Interleukin Related
Application Notes:
MCE Product type: Reference compound
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