Hydralazine-d4 (hydrochloride), CAS [[2749234-32-8]]

Product Overview

• Article Name: Hydralazine-d4 (hydrochloride), CAS [[2749234-32-8]]
• Biozol Catalog Number: MCE-HY-B0464S
• Supplier Catalog Number: HY-B0464S
• Alternative Catalog Number: MCE-HY-B0464S-1MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

Hydralazine-d4 hydrochloride is the deuterium labeled Hydralazine hydrochloride. Hydralazine hydrochloride is an orally active, blood-brain barrier-permeable DNA methyltransferase inhibitor with vasodilatory, arterial smooth muscle relaxant and hypotensive activities. Hydralazine hydrochloride reactivates silenced tumor suppressor genes via mediating DNA demethylation, while exerting neuroprotective and anti-inflammatory properties. Hydralazine hydrochloride inhibits NOS-2 (iNOS) and COX-2, and reduces the production of NO and PGEE2, meanwhile, Hydralazine hydrochloride scavenges reactive oxygen species and inhibits macrophage activation. Hydralazine hydrochloride alleviates motor dysfunction, neuropathic inflammatory pain, and formalin-induced somatic and emotional pain responses. In addition, Hydralazine hydrochloride directly induces DNA strand breaks and sister chromatid exchange, exhibiting certain mutagenic characteristics. Hydralazine hydrochloride has been widely used in studies on hypertension, various cancers (such as cervical cancer, leukemia), spinal cord injury and the mechanisms of inflammatory pain[1][2][3][4][5].

Product Properties

• Molecular Weight: 200.66
• Purity: 0.997
• CAS Number: [2749234-32-8]
• Formula: C8H5D4ClN4
• Target: COX,DNA Methyltransferase,Isotope-Labeled Compounds,NO Synthase,PGE synthase,Reactive Oxygen Species (ROS)

Application Notes

• Application Notes: MCE Product type: Isotope-Labeled Compounds