Articaine (Hoe-045) is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC50 of 15.8 µM for open-state Na+ channels, and IC50 of 40.6 µM and 378 µM for inactivated and resting-state Na+ channels, respectively. Articaine exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-kappaB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury)[1][2][3].
Molecular Weight:
284.37
CAS Number:
[23964-58-1]
Formula:
C13H20N2O3S
Target:
NF-kappaB,NOD-like Receptor (NLR),Sodium Channel
Application Notes:
Reference compound
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