Articaine (Standard), CAS [[23964-58-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-B0516AR
Supplier Catalog Number:
HY-B0516AR
Alternative Catalog Number:
MCE-HY-B0516AR-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
Hoe-045 (free base) (Standard)
Articaine (Standard) is the analytical standard of Articaine (HY-B0516A). This product is intended for research and analytical applications. Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC50 of 15.8 µM for open-state Na+ channels, and IC50 of 40.6 µM and 378 µM for inactivated and resting-state Na+ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-kappaB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury)[1][2][3].
