Anagrelide is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide inhibits bone marrow megakaryocytopoiesis. Anagrelide decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide is a platelet-lowering agent and plays in the antithrombopoietic action[1][2][3].
Molecular Weight:
256.09
Purity:
99.87
CAS Number:
[68475-42-3]
Formula:
C10H7Cl2N3O
Target:
Apoptosis,Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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