Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action[1][2][3].
Molecular Weight:
292.55
Purity:
99.39
CAS Number:
[58579-51-4]
Formula:
C10H8Cl3N3O
Target:
Apoptosis,Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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