Doxapram is a respiratory stimulant. Doxapram increases breathing rate and depth by acting on the brains respiratory centers and peripheral chemoreceptors. Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50s of 410 nM, 37 µM, 9 µM, respectively. Doxapram inhibits the Ca-activated potassium current (IC50 ~ 13 µM) and Ca-independent potassium current (IC50 ~ 20 µM) in type I cells of the carotid body. Doxapram significantly prolongs the effective refractory period of the atrium and has an anti-arrhythmic effect. Doxapram can be used for the study of respiratory depression such as post-anesthesia respiratory depression, chronic obstructive pulmonary disease and apnea of prematurity[1][2][3][4][5][6].
Molecular Weight:
378.51
Purity:
99.70
CAS Number:
[309-29-5]
Formula:
C24H30N2O2
Target:
Potassium Channel
Application Notes:
MCE Product type: Reference compound
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