Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca2+ concentration (Ca2+ release) with an EC50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinsons disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue[1][2][3].
Molecular Weight:
405.41
Purity:
99.91
CAS Number:
[103300-74-9]
Formula:
C17H23N7O5
Target:
Apoptosis,Thyroid Hormone Receptor
Application Notes:
MCE Product type: Reference compound
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