Metaxalone (AHR438, NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1beta-induced inflammatory phenotype, modulates NF-kappaB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1beta-treated microglia[1][2].
Molecular Weight:
221.26
Purity:
99.95
CAS Number:
[1665-48-1]
Formula:
C12H15NO3
Target:
NF-kappaB,PGC-1alpha
Application Notes:
MCE Product type: Reference compound
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