Tiagabine hydrochloride is an anticonvulsant agent and a selective inhibitor of the GAT-1 GABA transporter with a Ki of ~0.1 µM. Tiagabine hydrochloride potently and selectively inhibits GABA reuptake with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in synaptosomes, neurons and glia, respectively. Tiagabine hydrochloride has neuroprotective properties[1][2][3][4][5][6][7][8].
Molecular Weight:
412.01
Purity:
99.44
CAS Number:
[145821-59-6]
Formula:
C20H26ClNO2S2
Target:
GABA Receptor,Trk Receptor
Application Notes:
MCE Product type: Reference compound
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