Fimasartan (BRA-657) is an orally effective angiotensin receptor AT1 non-peptide antagonist. Fimasartan has antihypertensive effects. Fimasartan improves neuroinflammation and brain injury mediated by NLRP3 inflammatome after intracerebral hemorrhage, and has neuroprotective effect. Fimasartan inhibits the expression of inducible nitric oxide synthase through the inactivation of NF-kappaB and activator protein-1[1][2][3].
Molecular Weight:
501.65
Purity:
99.60
CAS Number:
[247257-48-3]
Formula:
C27H31N7OS
Target:
Angiotensin Receptor,Apoptosis,NF-kappaB
Application Notes:
MCE Product type: Reference compound
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