Propoxur-d3 is the deuterated form of Propoxur (HY-B0916). Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction, on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests[1][2][3][4].
Molecular Weight:
212.26
CAS Number:
[1219798-56-7]
Formula:
C11H12D3NO3
Target:
Cholinesterase (ChE),ERK,Insecticide,Isotope-Labeled Compounds,Keap1-Nrf2,MMP,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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