Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models[1][2][3].
Molecular Weight:
289.55
Purity:
99.98
CAS Number:
[3380-34-5]
Formula:
C12H7Cl3O2
Target:
Antibiotic,Apoptosis,Bacterial,Fungal
Application Notes:
MCE Product type: Reference compound
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