(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels[1]. (+)-Kavain is shown to bind at the alpha4beta2delta GABAA receptor and potentiate GABA efficacy[2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied[4].
Molecular Weight:
230.263
Purity:
99.98
CAS Number:
[500-64-1]
Formula:
C14H14O3
Target:
Calcium Channel,GABA Receptor,Sodium Channel
Application Notes:
Natural Products
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