Tracazolate (ICI 136753) hydrochloride is a potent GABAA receptor modulator. Tracazolate hydrochloride has selectivity for beta3 and potentiates alpha1beta1gamma2s (EC50=13.2 µM), alpha1beta3gamma2 (EC50=1.5 µM). Tracazolate hydrochloride has the potency (EC50) determined by the nature of the third subunit (gamma1-3, delta, epsilon) within the receptor complex. Tracazolate hydrochloride possesses anxiolytic and anticonvulsant activity[1][2].
Molecular Weight:
340.85
Purity:
99.24
CAS Number:
[1135210-68-2]
Formula:
C16H25ClN4O2
Target:
GABA Receptor
Application Notes:
MCE Product type: Reference compound
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