Zaprinast (M&B 22948) is a selective inhibitor of cGMP-selective Phosphodiesterase (PDE5). Zaprinast causes a significant increase in cGMP levels in myocytes. Zaprinast is a G protein-coupled receptor 35 (GPR35) agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects[1][2][3].
Molecular Weight:
271.27
Purity:
99.88
CAS Number:
[37762-06-4]
Formula:
C13H13N5O2
Target:
GPR35 ,Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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