2-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2-deoxyuridine, EdU (HY-118411). 2-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Abeta25-35-induced brain injury, which is promising for research of Alzheimers disease (AD)[1][2][3].
Molecular Weight:
228.20
Purity:
99.98
CAS Number:
[951-78-0]
Formula:
C9H12N2O5
Target:
Endogenous Metabolite,Thymidylate Synthase
Application Notes:
Natural Products
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