N-Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c-Abl inhibitor, and a substrate of P-glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated alpha-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib shows significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) models with mild SARS-CoV-2 infection. N-Desmethyl imatinib can be used for the research of Parkinsons disease, gastrointestinal stromal tumor, and chronic myeloid leukemia[1][2][3].
Molecular Weight:
479.59
Purity:
99.77
CAS Number:
[404844-02-6]
Formula:
C28H29N7O
Target:
Apoptosis,Drug Metabolite,P-glycoprotein
Application Notes:
MCE Product type: Reference compound1
* VAT and and shipping costs not included. Errors and price changes excepted
