N-Desmethyl imatinib mesylate (Norimatinib mesylate) is an active metabolite of Imatinib (HY-15463), a selective c-Abl inhibitor, and a substrate of P-glycoprotein. N-Desmethyl imatinib mesylate binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated alpha-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib mesylate induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib mesylate exhibits significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) settings following mild SARS CoV 2 infection. N-Desmethyl imatinib mesylate can be used for the research of Parkinsons disease, gastrointestinal stromal tumor, and chronic myeloid leukemia[1][2][3].
Molecular Weight:
575.68
CAS Number:
[404844-03-7]
Formula:
C29H33N7O4S
Target:
Apoptosis,Drug Metabolite,P-glycoprotein
Application Notes:
MCE Product type: Reference compound1
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