2-Acetylacteoside (2-AA) is a natural compound with oral activity and blood-brain barrier permeability. 2-Acetylacteosideexhibits MAO-B inhibitory activity (IC50 = 17.71 µM, Ki = 13.81 µM). 2-Acetylacteoside downregulates the expression of RANK, TRAF6, NF-kappaB, NFATc1 and IKKbeta, disrupts the RANKL/RANK interaction, blocks downstream signaling pathways, and increases the level of phosphorylated Akt. 2-Acetylacteoside possesses potent anti-osteoclastogenic, anti-bone resorptive, pro-neurogenic, neuroprotective and antioxidant activities. 2-Acetylacteoside can be used in the research of osteoporosis, ischemic stroke and Parkinsons disease[1][2][3][4].
