Stigmasterol is an orally acitve, immunomodulatory agent with anti-inflammatory and neuroprotective effect, as well as able to cross the blood-brain barrier. Stigmasterol activates AMPK, which in turn inhibits NF-kappaB and NLRP3 signaling pathways, reduces microglia-mediated neuroinflammation, and alleviates cognitive impairment and Alzheimers disease. Stigmasterol regulates M1/M2 polarization of microglia through the TLR4/ NF-kappaB pathway, thereby reducing neuropathic pain. Stigmasterol can be used for neurodegenerative diseases, inflammatory diseases, and pain management, among others[1][2][3][4][5].
Molecular Weight:
412.69
Purity:
98.48
CAS Number:
[83-48-7]
Formula:
C29H48O
Target:
Endogenous Metabolite,MMP
Application Notes:
MCE Product type: Natural Products
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