Benzoylaconine (Benzoylaconitine) is an orally active monoester alkaloid found in the traditional Chinese medicine Aconitum carmichaelii. Benzoylaconine is an ACE2 agonist (EC50: 1.5 µM) with antihypertensive and anti-heart failure effects. Benzoylaconine inhibits TLR-induced MAPK and NF-kappaB pathways to exert anti-inflammatory effects. Benzoylaconine upregulates the protein levels of P-gp, MRP2, and has anti-tumor effects[1][2][3][4][5][6].
Molecular Weight:
603.70
Purity:
99.92
CAS Number:
[466-24-0]
Formula:
C32H45NO10
Target:
Angiotensin-converting Enzyme (ACE),COX,NF-kappaB,NO Synthase,p38 MAPK,P-glycoprotein,Reactive Oxygen Species (ROS),Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Natural Products
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