Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 µM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 µM), and may protect against Alzheimer disease[1]. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKalpha/Akt pathways[2]. Epiberberine has the potential effect in the research of diabetic disease[3].
Molecular Weight:
371.81
Purity:
98.91
CAS Number:
[889665-86-5]
Formula:
C20H18ClNO4
Target:
Beta-secretase,Cholinesterase (ChE),Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Natural Products
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