Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-kappaB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury[1][2][3][4][5][6].
Molecular Weight:
472.70
Purity:
99.95
CAS Number:
[465-99-6]
Formula:
C30H48O4
Target:
COX,NF-kappaB
Application Notes:
MCE Product type: Natural Products
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