Hypaconitine inhibits the KCNH2 current with an IC50 of 8.1 nM, and exhibits cardiotoxicity. Hypaconitine inhibits TGF-beta1-induced epithelial-mesenchymal transition (EMT) in A549 cell through the inhibition of NF-kappaB nuclear translocation. Hypaconitine acts as the neuromuscular blocker. Hypaconitine is orally active[1][2][3][4].
Molecular Weight:
615.71
Purity:
99.49
CAS Number:
[6900-87-4]
Formula:
C33H45NO10
Target:
Calcium Channel,NF-kappaB,Potassium Channel
Application Notes:
MCE Product type: Natural Products
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