Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 µM, 9.33 µM and 25.01 µM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-alpha, IL-1beta, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4].
Molecular Weight:
178.14
Purity:
99.77
CAS Number:
[486-35-1]
Formula:
C9H6O4
Target:
Akt,AMPK,Apoptosis,Autophagy,Bcl-2 Family,Caspase,EGFR,mTOR,Parasite,PARP,PKA,PKC,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Natural Products
* VAT and and shipping costs not included. Errors and price changes excepted
