Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimers disease, Huntingtons disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC50=16.65 µM)[1]. Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells[2]. Idebenone quickly crosses the blood-brain barrier.
Molecular Weight:
338.44
Purity:
99.84
CAS Number:
[58186-27-9]
Formula:
C19H30O5
Target:
Apoptosis,Mitochondrial Metabolism
Application Notes:
MCE Product type: Reference compound
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