Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIbeta), fetuin-A, NF-kappaB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-kappaB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc[1][2][3].
Molecular Weight:
388.45
Purity:
99.97
CAS Number:
[66280-25-9]
Formula:
C22H28O6
Target:
AMPK,CaMK,Keap1-Nrf2,NF-kappaB,NO Synthase
Application Notes:
MCE Product type: Natural Products
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