Polygalasaponin F is an orally active triterpenoid saponin monomer. Polygalasaponin F downregulates the expression of Bax, p53, caspase-3, NF-kappaB p65 and MEK1, restores and upregulates the expression of Bcl-2, activates the PI3K/Akt signaling pathway, inhibits the phosphorylation of p38 MAPK, nuclear translocation of NF-kappaB, TLR4-mediated signaling pathway, mitophagy (Mitophagy) and ROS production, enhances cell viability and suppresses apoptosis (Apoptosis). Polygalasaponin F maintains mitochondrial function, alleviates Ca2+ overload, upregulates pCREB and BDNF, preserves cell viability and inhibits the release of inflammatory cytokines. Polygalasaponin F alleviates lung injury induced by influenza A H1N1 and cerebral ischemia-reperfusion injury. Polygalasaponin F is applicable to researches related to Parkinsons disease, cerebral ischemia, pneumonia induced by influenza A H1N1, stroke and Alzheimers disease[1][2][3][4][5][6][7].
Molecular Weight:
1091.24
Purity:
99.85
CAS Number:
[882664-74-6]
Formula:
C53H86O23
Target:
Akt,Apoptosis,Bcl-2 Family,Calcium Channel,Caspase,MDM-2/p53,MEK,Mitophagy,NF-kappaB,p38 MAPK,PI3K,Reactive Oxygen Species (ROS),Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Natural Products
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