10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC50 value of 10.47 µM against DPPH radical, an IC50 value of 1.68 µM against superoxide radical and an IC50 value of 1.35 µM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 µM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol is promising for research of ulcerative colitis[1][2][3][4][5].
Molecular Weight:
350.49
Purity:
99.34
CAS Number:
[23513-15-7]
Formula:
C21H34O4
Target:
Akt,AMPK,Apoptosis,Interleukin Related,PI3K,Reactive Oxygen Species (ROS),TNF Receptor
Application Notes:
MCE Product type: Natural Products
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