(+)-Magnoflorine (alpha-Magnoflorine) chloride is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine chloride promotes Parkin/PINK1-mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine chloride inhibits JNK and TLR4/NF-kappaB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine chloride upregulates miR-410-3p, inhibits HMGB1/NF-kappaB pathway, and has anti-tumor activity. (+)-Magnoflorine chloride also has significant antifungal activity[1][2][3][4][5][6][7].
Molecular Weight:
377.86
Purity:
99.29
CAS Number:
[6681-18-1]
Formula:
C20H24ClNO4
Target:
AMPK,Apoptosis,Autophagy,Caspase,Fungal,JNK,NF-kappaB,NOD-like Receptor (NLR),PINK1/Parkin,Reactive Oxygen Species (ROS),Sirtuin
Application Notes:
MCE Product type: Natural Products
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