Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 µM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCepsilon without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer[1][2][3].
Molecular Weight:
314.25
Purity:
99.93
CAS Number:
[524-12-9]
Formula:
C16H10O7
Target:
Apoptosis,Caspase,Lipoxygenase
Application Notes:
MCE Product type: Natural Products
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