Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-kappaB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing[1][2][3][4][5].
Molecular Weight:
422.34
Purity:
99.60
CAS Number:
[24699-16-9]
Formula:
C19H18O11
Target:
Acetyl-CoA Carboxylase,AMPK,Apoptosis,Bacterial,HSV,NF-kappaB,NOD-like Receptor (NLR),Reactive Oxygen Species (ROS),VEGFR
Application Notes:
MCE Product type: Natural Products
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